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Our Canadian pharmacy partner offers only genuine FDA approved
Taxol and generic Paclitaxel - mostly to people who need relief
from the astronomical cost of treatment they face when buying
the exact same medication in the United States.
Through our partner we offer a legal, reliable, and reputable
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Antitumor and antileukemic agent
isolated from the bark of the yew tree, Taxus brevifolia. Wani,
M.C., et al. "Plant antitumor agents. VI. The isolation and
structure of taxol, a novel antileukemic and antitumor agent
from Taxus brevifolia." J. Am. Chem. Soc. 93: 2325-2327 (1971).
McGuire, W.P., et al. "Taxol: a unique antineoplastic agent with
significant activity in advanced ovarian epithelial neoplasms"
Ann. Int. Med. 111: 273-279 (1989).
Binds to β-tubulin and promotes the assembly of microtubules
that resist depolymerization preventing normal cell division.
Rowinsky, E.K., et al. "Taxol: a novel investigational
antimicrotubule agent." J. Natl. Cancer Inst. 82: 1247-1259
(1990). Parekh, H. and Simpkins, H. "The transport and binding
of taxol." Gen. Pharmacol. 29: 167-172 (1997). Jordan, A., et
al. "Tubulin as a target for anticancer drugs: agents which
interact with the mitotic spindle investigational
antimicrotubule agent." Med. Res. Rev. 18: 259-296 (1998).
Induces apoptosis through a JNK-dependent pathway in the early
phase followed by a JNK-independent pathway that results in
Bcl-2 phosphorylation. Wang, T.H., et al. "Microtubule
dysfunction induced by paclitaxel initiates apoptosis through
both c-Jun N-termnial kinase (JNK)-dependent and -independent
pathways in overian cancer cells." J. Biol. Chem. 274: 8208-8216
(1999). Shtil, A.A., et al. "Differential regulation of mitogen-activated
protein kinases by microtubule-binding agents in human breast
cancer cells." Oncogene 18: 377-384 (1999). Srivastava, R.K., et
al. "Involvement of microtubules in the regulation of Bcl2
phosphorylation and apoptosis through cyclic AMP-dependent
protein kinase." Mol. Cell. Biol. 18: 3509-3517 (1998). Torres,
K., and Horwitz, S.B. "Mechanisms of Taxol-induced cell death
are concentration dependent." Cancer Res. 58: 3620-3626 (1998).
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