Buy Paclitaxel for
Research
Paclitaxel
Storage:
Store at or below -20 șC.
Solubility:
Soluble in DMSO (up to about 200 mg/mL) or ethanol (up to about
40 mg/mL).
Disposal: A
Info:
Paclitaxel MSDS
Research Use
Aside from its direct clinical use, taxol is used extensively in
biological and biomedical research as a microtubule stabilizer.
In vitro assays involving microtubules, such as motility assays,
generally rely on Taxol to maintain microtubule integrity in the
absence of the various nucleating factors and other stabilizing
elements found in the cell. For example, it is used for in vitro
tests of drugs that aim to alter the behavior of microtubule
motor proteins, or for studies of mutant motor proteins. Taxol
is sometimes used for in vivo studies as well; in can be fed to
test organisms such as fruit flies or injected into individual
cells, to inhibit microtubule disassembly or to increase the
number of microtubules in the cell.
Structural Diagram 2D
Sold for laboratory or
manufacturing purposes only; not for human, veterinary, food, or
household use.
We ship to all countries/destinations from the
United States. All forms of payment accepted.
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Daniel Chewning
Principal
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Medical Innovations
Point Pleasant Beach, NJ
United States
Antitumor and antileukemic agent
isolated from the bark of the yew tree, Taxus brevifolia. Wani,
M.C., et al. "Plant antitumor agents. VI. The isolation and
structure of taxol, a novel antileukemic and antitumor agent
from Taxus brevifolia." J. Am. Chem. Soc. 93: 2325-2327 (1971).
McGuire, W.P., et al. "Taxol: a unique antineoplastic agent with
significant activity in advanced ovarian epithelial neoplasms"
Ann. Int. Med. 111: 273-279 (1989).
Binds to β-tubulin and promotes the assembly of microtubules
that resist depolymerization preventing normal cell division.
Rowinsky, E.K., et al. "Taxol: a novel investigational
antimicrotubule agent." J. Natl. Cancer Inst. 82: 1247-1259
(1990). Parekh, H. and Simpkins, H. "The transport and binding
of taxol." Gen. Pharmacol. 29: 167-172 (1997). Jordan, A., et
al. "Tubulin as a target for anticancer drugs: agents which
interact with the mitotic spindle investigational
antimicrotubule agent." Med. Res. Rev. 18: 259-296 (1998).
Induces apoptosis through a JNK-dependent pathway in the early
phase followed by a JNK-independent pathway that results in
Bcl-2 phosphorylation. Wang, T.H., et al. "Microtubule
dysfunction induced by paclitaxel initiates apoptosis through
both c-Jun N-termnial kinase (JNK)-dependent and -independent
pathways in overian cancer cells." J. Biol. Chem. 274: 8208-8216
(1999). Shtil, A.A., et al. "Differential regulation of mitogen-activated
protein kinases by microtubule-binding agents in human breast
cancer cells." Oncogene 18: 377-384 (1999). Srivastava, R.K., et
al. "Involvement of microtubules in the regulation of Bcl2
phosphorylation and apoptosis through cyclic AMP-dependent
protein kinase." Mol. Cell. Biol. 18: 3509-3517 (1998). Torres,
K., and Horwitz, S.B. "Mechanisms of Taxol-induced cell death
are concentration dependent." Cancer Res. 58: 3620-3626 (1998).
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